05. Radiation Toxicity

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 Radiation Toxicity Medical effects of radiation exposure can be divided into two categories known as Acute Radiation Syndrome (ARS) and Delayed Effects of Acute Radiation Exposure (DEARE)Acute radiation exposure consists of health effects that immediately exposure of the body to a relatively high dose (>2-5Gy) delivered with high dose rate. ARS is visible as three syndromes based on the radiosensitivity of organs. Those are Hematopoietic syndrome (occurring after exposure 0.7-10Gy), Gastrointestinal syndrome (usually greater than 10 Gy), and Cardiovascular/Central nervous system syndrome ( dose greater than >50 Gy).DEARE is visible months or years after the radiation exposure symptoms such as prolonged gastrointestinal dysfunction, skin injury, renal failure, and lung injury. Radiation-induced damage occurs from long-lived free radicals, reactive oxygen species, and pro-inflammatory cytokines/chemokines which damage the recovery and repopulation of stem cells. The limita...
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