05. Radiation Toxicity

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 Radiation Toxicity Medical effects of radiation exposure can be divided into two categories known as Acute Radiation Syndrome (ARS) and Delayed Effects of Acute Radiation Exposure (DEARE)Acute radiation exposure consists of health effects that immediately exposure of the body to a relatively high dose (>2-5Gy) delivered with high dose rate. ARS is visible as three syndromes based on the radiosensitivity of organs. Those are Hematopoietic syndrome (occurring after exposure 0.7-10Gy), Gastrointestinal syndrome (usually greater than 10 Gy), and Cardiovascular/Central nervous system syndrome ( dose greater than >50 Gy).DEARE is visible months or years after the radiation exposure symptoms such as prolonged gastrointestinal dysfunction, skin injury, renal failure, and lung injury. Radiation-induced damage occurs from long-lived free radicals, reactive oxygen species, and pro-inflammatory cytokines/chemokines which damage the recovery and repopulation of stem cells. The limita...

04. Biological effects of Non ionizing radiation

 Biological effects of Non ionizing radiation

Non-ionizing radiation can define lower-range frequency waves in the electromagnetic range, and travel in space with the power of oscillating electric and magnetic fields. The difference between ionizing and non-ionization is, non-ionizing radiation energy is too low to process the ionizing process which expels electrons from the coulomb attraction of the nucleus. But it can transfer an electron from a low-energy state to a high-energy state. This excitation process can be induced risk to health by non-ionizing radiation.


According to the energy of photons, different types of non-ionizing radiation energy decrease from ultraviolet radiation to radio waves.

 Copyrights: https://www.osha.gov/radiation

 Ultraviolet radiation (UV) has a shorter wavelength than light and longer than X-rays. When certain cells are exposed to UV radiation the damage is induced by both photochemical and heating reactions. Photochemical effects are when radiation hit the molecule and its energy initiates the excitation of electrons in the molecules and causes them to change the molecular structure and produce different products. Photosynthesis also has this mechanism but is not identical. Molecules or regions of molecules that absorb UV radiation are called chromophores. Excited chromophores can transfer their energy or donate an electron to O2 and form Oxygen Relative Species (ROS) which bind other chemical Infrastructures and change their usual formation. ROS species are superoxide anion radical (O2-) or singlet oxygen (1O2) through transfer energy Superoxide dismutase which is present in the extracellular matrix converts O2- into H2O2.In presence of Fe (II), it undergoes a Fenton reaction and produces OH- which causes damage to both DNA and Proteins. And also, UV radiation specially induced DNA damage by the formation of electronically excited states in pyrimidine bases. Pyrimidine bases include cytosine, thymine, and uracil. Excitations from UV radiation cause rearrange of the double bonds between C5 and C6 in adjacent pyrimidines called cyclobutene pyrimidine dimers (CPDs). CPDs are major DNA damage induced by sunlight.

Visible light also causes excitation. For example, blue light has high energy, and prolonged exposure to blue light emitted from computers, televisions, and other electronic devices causes loss of central vision by damaging cone cells in the eyes. LASER also produces optical amplification based on the stimulated emission of electromagnetic radiation which relatively have high energy than normal optical radiation. LASER also causes skin burns and hazards for cataracts.


Infrared radiation (IR) has a lengthier wavelength than UV but is small than radiofrequency.IR can excite molecules that vibrate to gain energy to their molecular stage which produces heat. The primary source of infrared radiation is heat or thermal reaction and temperature radiates in the infrared.IR causes skin response such as pain and prolonged exposure cause for damage cornea and retina through burns. But IR also uses for therapeutic effects which use IR produce heat in a biological system to accelerate chemical reactions by increasing heat and its relief to treatment of autoimmune diseases, wound and ulcer healing, improving hair growth, pain relief, and improving skin appearance. In sports medicine use IR therapy to treat muscle injuries. Infrared astronomy uses to identify water from distant planets which orbit around stars. When emitting light from stars absorb by water in the planet and changes its frequency and this is observed by infrared telescopes such as Hubble and Spitzer telescopes to identify atmospheric characteristics of that planet or other planets in the planetary system.

 

Microwave radiation is widely used for telecommunication (Low frequency) and heating or defrosting food (High frequency). Microwaves produce by mobile phones and their base stations, Bluetooth devices, wireless local area networks, and many other communication applications the body's high exposure to Microwaves will damage the tissues through their thermal activity. it can vibrate by interacting with the dipole of water molecules which incident happen in microwave oven this especially vulnerable activity to the central nervous system can cause sleep deprivation, memory impairment, and the leading chance of developing brain tumor in which organs contain more water. depth of travel of a microwave depends on its frequency. These effects are not instantly apparent as lower frequencies can penetrate more through the tissues. Prolonged microwave radiation also causes effects on reproductive organs such as severe damage to testicles in the male by disrupting seminiferous tubules and reducing the Leydig cell population which causes reduced testosterone concentration. But microwaves also use for medical purposes by using their heating activity in localized regions providing precise tissue destruction in medical purposes. Tissue loss occurs when tissues from a selected electromagnetic field usually at 900-2500MHz.

 

Extremely low-frequency radiation mainly uses for telecommunication industries but prolonged exposure may induce epidemiological effects, cancer, depression and increase free radical concentration and recombination of free radical couples and resulting in oxidative stress. Extremely low-frequency radiation uses in diagnostic aquation modalities such as MRI, and microwave imaging.

 

In conclusion, reducing exposure to ionizing radiation and also non -ionizing radiation is also significant because both radiation cause changes in molecular structures in ionizing or excitation. Monitoring the dose will be reduced the significant health risk and cancer probability.


Stay Tuned !

Linkedin: Sachindra Lochana


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